PENULARAN PENYAKIT KUSTA BERDASARKAN PENGUKURAN KADAR ANTIBODI ANTI PGL-1 PADA NARAKONTAK DI KECAMATAN PRAGAAN KABUPATEN SUMENEP

Abstract

Leprosy is a chronic disease caused by Mycobacterium leprae and primarily attacks the peripheral nerves and then causes manifestation on the skin.  in certain types, it also attacks the upper respiratory tract mucosa. Leprosy is a problem faced by most people of the world especially in developing countries that has yet to be resolved in accordance with the target population prevalence of less than 1/10.000. The purpose of this study is to analyze the factors that influence the transmission of leprosy  based on measurement of antibody levels of  anti PGL-1 in contact in District Pragaan Sumenep. The study design using crossectional approach. Sample is taken with simple random sampling technique as much as 60 respondents who had contact with MB leprosy patients in District Pragaan Sumenep in 2011 with a maximum radius of 10 meters. The research data was taken with a sampling of peripheral blood in the fingertips of contact to know the PGL-1 Positive infected or not. The observations on the respondent is then performed to determine the characteristics of gender, age, economic status , nutritional status, water use, residential density, and contacts (old contacts, intensive contacts and household contacts). To see the influence of each variable used Logistic Regression analysis. The result of serological examination of IgM antibodies against PGL-1 on all respondents 15% of respondents obtained a positive result of contracting leprosy subclinical. The result shows there is no influence of gender, age, economic status, nutritional status, water use, residential density and household contacts with leprosy transmission in the District Pragaan Sumenep. In other way, intensive contact values ​​obtained P values ​​0.027 and p value of long contact is 0.000. It can indicate that there is the influence of intensive contact and prolonged contact against the transmission of leprosy in the district Pragaan tahun2011 Sumenep. After learning of the results of this study it is advisable to people to reduce the frequency of contact with MB leprosy patients  to avoid the transmission process, and advocate on health care in order to increase health promotion dan prevention efforts so that the leprosy can be eliminated.